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Journal Club | Regulation of mitochondria fission by ER-mito contacts


Speaker:Yiwen Zhang (张怡文) Ran Liu (刘然) Minming Wang (王闽铭)


In eukaryotic cells, mitochondria exist as a highly interconnected tubular network that undergoes continuous fission and fusion events. Disturbed mitochondrial dynamics have been shown to mediate various neurodegenerative disorders. It is well established that dynamin-related protein (DRP1) mediates mitochondrial fission by wrapping around the constriction points of dividing mitochondria. It’s been over six decades since the discovery and characterization of the Architecture at Mitochondria-Associated Membranes (MAMs). Recent researches have demonstrated that the endoplasmic reticulum plays a role in determining mitochondrial division sites through players like ER-associated formin, actin, and mtDNA synthesis. These new findings indicate that organelles within a cell are not isolated entities, but are closely connected in complex ways.

Guest information:

Dr. Ye Tian (CAS)

Dr. Quan Chen (CAS)

Recommend Literatures:


Lee, Hakjoo, and Yisang Yoon. "Mitochondrial fission: regulation and ER connection." Molecules and cells 37.2 (2014): 89.


1. Friedman, Jonathan R., et al. "ER tubules mark sites of mitochondrial division." Science 334.6054 (2011): 358-362.

2. Lewis, Samantha C., Lauren F. Uchiyama, and Jodi Nunnari. "ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells." Science 353.6296 (2016): aaf5549.