[Journal Club] Mechanisms of limb RegenerationJun.03.2018
Speaker：Yuan Fang (房苑) Ke Bai (白珂) Zhonggang Jiao (焦中罡)
The vertebrate limb is a complex structure originating from a small bud of undifferentiated mesoderm cells. In most vertebrates, including human, the limb is unable to regenerate after severe injury or amputation, resulting in disability. However, some amphibians still possess the capacity to regenerate a fully patterned, functional limb in response to amputation, such as salamander. Understanding the mechanism of limb regeneration in these animals may provide methods to induce regeneration of human arms/legs or even other organs. During normal limb development in embryo, several signaling pathways coordinate to provide a precise positional and pattern information that directs proper limb growth, such as FGF, BMP, Wnt and Shh signaling. Whether limb regeneration adopt similar mechanisms is still under debate, since there exist many regeneration-specific behaviors. It would be interesting to study these regeneration behaviors, signaling pathways, pattern mechanisms and have a deep discussion on the several models proposed so far.
In this journal club, we are going to introduce the initiation, sustenance of limb regeneration and also the positional information that guides limb regeneration. In the discussion, we will focus on why we lose the regeneration ability as well as the implications from other regenerative models for regeneration in human.
Dr. Yang Zhao (赵扬) (Institute of Molecular Medicine, Peking University)
Dr. Ruimao Zheng (郑瑞茂) (School of Basic Medical Sciences, Peking University)
Tanaka EM. The Molecular and Cellular Choreography of Appendage Regeneration. Cell. 2016;165(7):1598-1608.
Gromberg E, Oliveira CR, Drechsel D, Nacu E, Tanaka EM. FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration. Nature, April 2016:1-16.
Anoop Kumar, James W. Godwin, et al. Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate. Science, Nov 2007;318(2):772-777